Clinco-Pathological and Biochemical Studies on Sheep Fed Aflatoxin Contaminated Ration

Document Type : Original Article


1 Pathological Department Animal Health Research Institute, Dokki, Egypt.

2 Biochemical Department Animal Health Research Institute, Dokki, Egypt.


Fifty sheep from Suez Governorate were suffered from high mortality rate (10% in the herd), weakness, depression, congestion of all mucous membrane and intestinal diarrhea. Ration analysis revealed presence of aflatoxin B1 , contamination (300 ppb). Hemogram, biochemical and histopathological examination demonstrated. Hemogram in aflatoxicated sheep showed significant decrease in red blood corpuscles (RBCs) count, Hemoglobin % and pack cell volume (PVC). Normocytic norm chronic anemia as well as leucopenia as compared to control values.
Hypoprotenemia, hypoalbumin, elevated liver and kidney enzyme were observed. Also, there was decrease in serum electrolyte (Ca, P, Mg, Na, K) as result of decrease re-absorption from the inflamed renal tubules. Also, demonstrated high residue of aflatoxin in liver, kidneys and muscles of affected sheep compared with normal one. Pathological examination of internal organs revealed severe damage in lung, heart, liver, kidney and intestine, that aflatoxins induced severe hepatic,
renal and cardiac lesions which cause mortalities. 


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