Antimicrobial activity of some cephalosporins with special reference to their effects on body weight and immune response to Newcastle disease vaccine in fayoumy chicks

Radwan, I. A.; Radi, Abeer M.

doi:10.21608/jvmr.2020.77607

Antimicrobial activity of some cephalosporins with special reference to their effects on body weight and immune response to Newcastle disease vaccine in fayoumy chicks

Document Type : Original Article

Authors

I. A. Radwan ¹
Abeer M. Radi ²

¹ Microbiology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.

² Pharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.

10.21608/jvmr.2020.77607

Abstract

The susceptibility of the most common bacterial pathogens, namely E. coli, P. mirabilis and Ps. aeroginosa which were isolated from egg incubators and yolk sacs of randomly selected one day old Fayoumy chicks to three selected cephalosporins (cephradine, ceftiofur and cefquinome) were studied. The minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC) of the tested drugs and the effect of these antibiotics on the body weight gain, mortality and immune response against Newcastle disease (ND) vaccine of the same bread of chicks were also estimated. The tested organisms were sensitive to ceftiofur and cefquinome whereas E.coli and ps. aeroginosa were found to be resistant to cephradine. The results showed that mortalities were higher in control and cephradine treated groups, while it was lower in the ceftiofur and cefquinome treated groups. On the other hand, the lowest mean body weight was recorded in control group (155.7±6.55 gm) followed by ceftiofur treated group (162.5±2.06 gm) and the highest mean body weight was recorded in cefquinome treated group (183.5±1.66 gm, p < 0.01) at 30 days of age. The study revealed that the tested antibiotics not exert any immune suppressive effect against (ND) vaccine.

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