Radiologic, Ultrasonic and pathological assessments of locally applied Chitosan on promotion of experimentally induced tibial fracture healing in rats

M. M. A, Kotb,; G. A., Ragab,; M. Z., Fathy,; U., Haggag,; M. Safwat, Nesreen

doi:10.21608/jvmr.2020.69691

Radiologic, Ultrasonic and pathological assessments of locally applied Chitosan on promotion of experimentally induced tibial fracture healing in rats

Document Type : Original Article

Authors

¹ Veterinarian in Garado Veterinary Unit, El- Fayoum, Egypt.

² Surgery, Anesthesiology and Radiology Department, Faculty of Veterinary Medicine, Beni-Suef Univ., Beni Suef, Egypt.

³ Pathology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef, Egypt.

10.21608/jvmr.2020.69691

Abstract

The objective of the present study was to evaluate the ability of Chitosan to promote induced tibial fracture healing in a rat model. The study was conducted on 14 albino rats divided into two equal groups (seven rats in each group). The first group was considered as a control group. The second group was injected Chitosan solution 0.1 mg/kg into the fracture gap. The progress of healing in each group was evaluated by clinical, radiography, ultrasonography and pathological examinations. The healing process was observed to be superior in the Chitosan group compared to the control one. Chitosan was found to promote healing of injured bone and is suggested to be used in cases of complicated or delayed bone fracture.

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