Antioxidant Effects of Syzygium cumini Fruit Pulp Extract against Cadmium-Induced Reproductive Toxicity

Document Type : Review article


1 Department of Biochemistry, Faculty of Veterinary Medicine, Minia University, El-Minia, 61519 Egypt.

2 Department of Physiology, Faculty of Veterinary Medicine, Minia University, Minia 61519, Egypt.

3 Department of Chemistry, Faculty of Sciences, Minia University, El-Minia, 61519 Egypt.

4 Department of Cytology and Histology, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef 62511, Egypt.


Although there are multiple environmental pollutants, heavy metals such as cadmium (Cd) represent the most serious one because of the oxidative stress they induce. The emerging evidence suggests that herbal medicine has become an essential alternative medical approach due to its natural identity and the lack of deleterious side effects. Many health benefits have been documented to phytochemicals such as flavonoids, polyphenols, alkaloids, and carotenoids, including putative antioxidant impacts thereby alleviating various oxidative stress conditions. Syzygium cumini is a type of plant that is rich in a variety of physiological phytochemical compounds. These compounds were observed to be present in various parts of the plant including leaves, seeds, peel, and pulp. Because of these compounds, the fruit of this plant is claimed to have anti-diabetic, anti-hyperlipidemic, antioxidant, hepatoprotective, antimicrobial, anti-inflammatory, antipyretic, antiplaque, radioprotective, neuropsycho-pharmacological, nephroprotective, and antidiarrheal properties as well as the ability to improve fertility in both male and females. The focus of this review is mainly on the antioxidant effects of Syzygium cumini fruit pulp extract against the reproductive challenges caused by exposure to cadmium. 


Main Subjects